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The compounds containing beryllium act as strong
2025-01-06

The compounds containing beryllium act as strong Lewis acids because of electron deficiency of the Be dATP solution []. Interactions of X-Be-Y compounds with different Lewis bases have been studied by Yanez and co-workers [], extensively. Recently, they proposed a class of extremely strong bidentat
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br Introduction Increasing number of mycosis infections has
2025-01-06

Introduction Increasing number of mycosis infections has been reported during the past several years because of the rise in the number of immuno-compromised individuals in subtropical and tropical countries with high mortality and morbidity [1], [2]. Trichophyton mentagrophytes, Trichophyton rubr
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Another issue is that the
2025-01-06

Another issue is that the vast majority of data from PET and CSF are from selected participants recruited through tertiary care dementia centers [176]. It is widely recognized that clinic-based participants differ from community-based studies, for example, the amount, type, and distribution of neuro
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Similarly compound was prepared from aldehyde d by following
2025-01-06

Similarly, Ryuvidine 13 was prepared from aldehyde 8d by following similar procedures (Scheme 3). Condensation of 13 with 7b or 7e provided the corresponding amides 9j or 9k, which then went through O-debenzylation by BCl3 to deliver the final compounds 10j and 10k in 37% and 32% overall yields, re
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The functional observations from the present study are based
2025-01-06

The functional observations from the present study are based on neoplastic deoxyuridine (HSY), and comparative expressions between normal salivary and pleomorphic adenoma tissues. However, there is a paucity of information on AhR expression and function in normal salivary gland, not neoplastic, cell
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The cavity volume of the binding pocket may
2025-01-06

The cavity volume of the binding pocket may differ not only between species but also among various AhR/ARNT isoforms within a single species. It is noteworthy that even a single amino BIX 02189 substitution within a binding pocket may result in a change in the cavity volume. This, in turn, may affe
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angiotensin 2 receptor blocker Since forskolin is known to a
2025-01-04

Since forskolin is known to act directly at the catalytic site of adenylate cyclases near the ATP binding (Tesmer et al., 1997), the synergistic and/or permissive effect of gonadotropins on FSK activity must occur at the level of AC itself or very near, at the level of one of its direct partner. The
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br Introduction Epilepsy is characterized by
2025-01-04

Introduction Epilepsy is characterized by spontaneous recurrent seizures and represents one of the most frequent neurological diseases affecting about 60 million people worldwide (McNamara, 1999). It is estimated that up to 50% of all cases are triggered by “initial precipitating injuries”, such
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Safingol The first suggestions that the cleaved intracellula
2025-01-04

The first suggestions that the cleaved intracellular domain of APP, AICD, might transit to the nucleus and hence selectively regulate gene transcription arose from analogies with the Notch receptor signalling system where similar intra-membrane proteolysis occurs [84], [85] and it was later confirme
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droperidol Acetylcholinesterase AChE activity and expression
2025-01-04

Acetylcholinesterase (AChE) activity and expression level can be down regulated by TCDD in neuronal cells [3], [6]. Thus AChE could be considered as a target of the neuronal toxicity of dioxin. AChE has several types of transcripts by alternative splicing in the 3′ region of primary transcripts [7]
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br Innate immune mechanisms that confront viral infection br
2025-01-04

Innate immune mechanisms that confront viral infection Autophagy induction by virus sensing Antiviral xenophagy and virophagy The presence of viral particles within autophagosomal structures has been visualized in only rare instances. This is the case for HSV-1 when it is devoided of ICP34.
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br Acknowledgements M M M is
2025-01-04

Acknowledgements M.M.M. is the William Dow Lovett Professor of Neurology and is supported by grants from the Michael J. Fox Foundation for Parkinson's Research, the American Parkinson Disease Association, the New Jersey Health Foundation/Nicholson Foundation, and by the National Institutes of Hea
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Hydrogen sulfide H S a colorless and
2025-01-04

Hydrogen sulfide (H2S) [33], a colorless and water-soluble gas with the smell of rotten eggs, is now recognized as an important gasotransmitter, after the extensive study of nitric oxide (NO) and carbon monoxide (CO). H2S is produced endogenously via enzymatic reactions of cysteine, homocysteine and
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The association of male gender with increased
2025-01-03

The association of male gender with increased atherosclerosis has stimulated interest in the role of androgen signalling in this condition. Androgens act (Fig. 2) by direct activation of androgen receptor (AR), a nuclear receptor that acts as a ligand-regulated transcription factor (Gao et al., 2005
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Deoxycholic acid In our sequential model for tau and A
2025-01-03

In our sequential model for tau and Aβ deposition, we included the tau deposition in the medial temporal Deoxycholic acid in the absence of Aβ deposition, which is a pathological definition of primary age-related tauopathy (PART). Although the tau pathologies in PART and AD are almost identical in
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